Vitamin D in CKD Patients

Vitamin D in CKD
Patients

Althoughvitamin D defciency is pandemic, the prevalence and severity of
vitamin D defciency is much more evident among CKD patients as
disclosed in all epidemiologic studies. Serum level of 25 OH D is the
most appropriate diagnostic test for vitamin D status [8]. Serum level
above 30 ng/mL (75 nmol/L) is considered sufcient, while a level
between 20 and 30 ng/mL (50-75 nmol/L) is considered as vitamin
D insufciency and level below 20 ng/mL (50 nmol/L) denotes
vitamin D defciency [8]. Vitamin D defciency is the cause of rickets in
children, and osteomalacia in adults. It may also predispose to various
diseases including cardiovascular, neoplastic, infectious, metabolic,
and autoimmune diseases. Vitamin D defciency accelerates the
progression of CKD. Vitamin D defciency results in activation of
the renin angiotensin system, transforming growth factor within
the kidney, decreased nephrin and podocin within the glomerular
basement membrane, and increased renal fbrosis [9,10].
Different factors are incriminated as causes of vitamin D defciency
among CKD patients. These factors include environmental and
culture factors, dietary restriction, diabetes and increased body mass
index [11]. UAE is also accused in as another cause of vit D defciency
[12]. While some studies reported signifcant association with age,
other studies failed to show similar association. Similar discrepancies
are observed regarding association with body weight, and diabetic
status.
According to KDIGO guidelines issued this month, patients with
CKD G3a– G5D, should have 25OHD levels measured repeatedly,
and vitamin D defciency and insufciency to be corrected using
treatment strategies recommended for the general population.
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12. Caravaca-Fontán F, Gonzales-Candia B, Luna E, Caravaca F. Relative importance of the determinants of serum levels of 25-hydroxy vitamin D in patients with
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References:
Vitamin D defciency is the cause
of rickets in children, and osteomalacia
in adults. It may also predispose
to various diseases including
cardiovascular, neoplastic, infectious,
metabolic, and autoimmune diseases
Different factors are incriminated as causes of vitamin
D deficiency among CKD patients. These factors
include environmental and culture factors, dietary
restriction, diabetes and increased body mass index