Downsterolin 10 mg/20 mg 

or

10 mg/40 mg film-coated Tablets 

Composition: 
Each tablet contains Ezetimibe10 mg and Simvastatin 20 mg or 40 mg.

Therapeutic indications: 
Prevention of Cardiovascular Events: 
DOWNSTEROLIN is indicated to reduce the risk of cardiovascular events in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS), either previously treated with a statin or not. 

Hypercholesterolaemia: 
DOWNSTEROLIN is indicated as adjunctive therapy to diet for use in patients with primary (heterozygous familial and non-familial) hypercholesterolemia or mixed hyperlipidaemia where use of a combination product is appropriate: 
• patients not appropriately controlled with a statin alone 
• patients already treated with a statin and ezetimibe 

Homozygous Familial Hypercholesterolaemia (HoFH) 
DOWNSTEROLIN is indicated as adjunctive therapy to diet for use in patients with HoFH.

 Patients may also receive adjunctive treatments (e.g. low-density lipoprotein [LDL] apheresis).